To establish and utilise a reverse translational clinical sample analysis derived from ethically obtained specimens from human patients in clinical trials for analysis (biomarkers, phenotype and transcription)
To perform clinical trials in humans with culture-expanded and minimally manipulated cell therapy.
To define strategies to identify, select and assess potency in clinically relevant cell populations.
To consider the relevant biology of stem cells and their sub populations in musculoskeletal regeneration.
To characterise the exogenous cell behaviour during repair and surgical intervention.
To understand endogenous stem cell behaviour in the context of targeted molecular approaches to joint surface repair.
To specify and utilise appropriate pre-clinical development.