2021
IN PRESS
Mennan C, Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt F, Zeggini E, Holt C, Roberts S. The Use of Technology in the Subcategorisation of Osteoarthritis: a Delphi Study Approach. Osteoarthritis and Cartilage Open.
Garcia J, Hulme C, Mennan C, Roberts S, Bastiaansen-Jenniskens YM, van Osch GJVM, Tins B, Gallacher P, Wright K. The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthritis and Cartilage Open.
Kyriacou H, Kamaraj A, Khan WS. Developments in antibiotic-eluting scaffolds for the treatment of osteomyelitis. Appl Sci (Basel).
Foster NC, Hall N, El Haj AJ. 2D and 3D cartilage model platforms for drug evaluation and high-throughput screening assays. Tissue Engineering Part B: Reviews.
Chisari E, Rehak L, Khan WS, Maffulli N. Tendon healing is adversely affected by low-grade inflammation. J Ortho Surg & Res.
PUBLISHED
Hotham WE, Thompson C, Szu-Ting L, Henson FMD. The anti-inflammatory effects of equine bone marrow stem cell-derived extracellular vesicles on autologous chondrocytes. Vet Record Open. 2021 Nov 10; 9(1) e22
Ali E, Birch M, Hopper N, Rushton N, McCaskie A. Human osteoblasts obtained from distinct periarticular sites demonstrate differences in biological function in vitro. Bone and Joint Research. 2021 Sep 27; 10(9):611-18
Chakrabarti S, Ai M, Wong K, Newell K, Henson FMD, St John Smith E. Functional characterization of ovine dorsal root ganglion neurons reveal peripheral sensitization after osteochondral defect. eNeuro. 2021 Sep 17;ENEURO.0237-21.2021. [Online ahead of print]
Loh B, Lim JA, Seah M, Khan WS. Perioperative management of open fractures in the lower limb. Journal of Perioperative Practice 2021 Jul 02 PMID: 34214004.
Eldridge SE, Barawi A, Roelofs A, Henson FMD, De Bari C, McCaskie AW, et al. AB0039 Agrin repairs bone and cartilage in vivo. Annals of the Rheumatic Diseases. 2021 June 80(Suppl 1):1052.1-1052.
Steinberg J, Southam L, Roumeliotis TI, Clark MJ, Jayasuriya RL, Swift D, Shah KM, Butterfield NC, Brooks RA, McCaskie AW, Bassett JHD, Williams GR, Choudhary JS, Wilkinson JM, Zeggini E. Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Ann Rheum Dis. 2021 Apr 26;annrheumdis-2020-219760 [Online ahead of print]
Kyriacou H, Mostafa AMHAM, Davies B, Khan WS. Principles and guidelines in the management of ankle fractures in adults. J Perioper Pract.2021 Apr 7:1750458920969029.[Online ahead of print]
Walker, M, I Will, A Pratt, V Chechik, P Genever, D Ungar. Magnetically-Triggered Release of Entrapped Bioactive Proteins from Thermally Responsive Polymer-Coated Iron Oxide Nanoparticles for Stem Cell Proliferation. ACS Appl. Nano Mater.2021; 3, 5008-5013.
Steinberg J, Southam L, Roumeliotis TI, Brooks RA, McCaskie AW et al. Nature Commun. 2021 Feb 26;12(1):1309.
Rocha RA, Fox JM, Genever PG, Hancock Y. Biomolecular phenotyping and heterogeneity assessment of mesenchymal stromal cells using label-free Raman spectroscopy. Sci Rep. 2021 Feb 23;11(1):4385.
Yeo EF, Markides H, Schade AT, Studd AJ, Oliver JM, Waters SL, El Haj AJ. Experimental and mathematical modelling of magnetically labelled mesenchymal stromal cell delivery. J R Soc Interface. 2021 Feb;18(175):20200558 Epub Feb 17
MacKay JW, Nezhad FS, Rifai T, Kaggie JD, Naish JH, Roberts C, Graves MJ, Waterton JC, Janiczek RL, Roberts AR, McCaskie A, Gilbert FJ, Parker GJM. Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study. Eur Radiol. 2021 Feb 16. [Online ahead of print]
Naseem, R; Tzivelekis, C; German, MJ; Gentile, P; Ferreira-Duarte, A & Dalgarno K. Strategies for enhancing polyester-based materials for bone fixation applications. Molecules. 2021, 26(4), 992.
Chan CD, Haagensen EJ, Tensaout HA, Rennie KJ, Gamie Z, Barry J, Birch MA, Gerrand CH, Sohail N, Robson CN, Lunec J, Rankin KS. Co localisation of intra nuclear membrane type 1 matrix metalloproteinase and hypoxia inducible factor 2α in osteosarcoma and prostate carcinoma cells. Oncology Letters. 2021 21(2):1–1.
Kyriacou H, Mostafa AMHAM, Davies B, Khan WS. Cost effectiveness analyses of total hip arthroplasty for hip osteoarthritis: A PRISMA systematic review. Int J Clin Pract. 2021 Feb;75(2):e13806
Garcia J, McCarthy HS, Kuiper JH, Melrose J, Roberts S. Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach? Biomolecules. 2021 Jan 13;11(1):E92.
Tomlinson F, Terschuur J, Henson FMD. Use of autologous products for the treatment of joint and soft tissue disease in horses: A systematic review. The Veterinary record. 2021 Jan; 188(2).
2020
Roelofs AJ, Kania K, Rafipay AJ, Sambale M, Kuwahara ST, Collins FL, Smeeton J, Serowoky MA, Rowley L, Wang H, Gronewold R, Kapeni C, Méndez-Ferrer S, Little CB, Bateman JF, Pap T, Mariani FV, Sherwood J, Crump JG, De Bari C. Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Ann Rheum Dis 2020, 79(12), 1625-1634.
Melo P, Kotlarz M, Marshall M, Magallanes M, Ferreira AM, Gentile P, Dalgarno K. Effects of alumina on the thermal processing of apatite-wollastonite: changes in sintering, microstructure and crystallinity of compressed pellets. Journal of the European Ceramic Society. Volume 40, Issue 15, December 2020, Pages 6107-6113. [online ahead of print]
Melo, P; Naseem, R; Corvaglia, I; Montalbano, G; Pontremoli, C; Azevedo, A; Quadros, P; Gentile, P; Ferreira, AM; Dalgarno, K; Vitale-Brovarone, C & Fiorilli, S. Processing of Sr2+ containing poly L-lactic acid based hybrid composites for additive manufacturing of bone scaffolds. Frontiers in Materials. 24 November 2020
Henson F, Lydon H, Birch M, Brooks R, McCaskie A. Using apheresis-derived cells to augment microdrilling in the treatment of chondral defects in an ovine model. J Orthop Res. 2020 Nov 4. [Online ahead of print]
Agarwal N, To K, Zhang B, Khan WS. Obesity does not adversely impact the outcome of unicompartmental knee arthroplasty for osteoarthritis: a meta-analysis of 80,798 subjects. Int J Obesity. 2020 Nov 19
Souter P, Vaughan J, Butcher K, Dowle A, Cunningham J, Dodd J, Hall M, Wilson D, Horner A, Genever P. Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants. Sci Rep. 2020 Nov 3;10(1):18950.
Kamaraj A, To K, Seah M, Khan WS. Modelling the cost-effectiveness of total knee arthroplasty: A systematic review. J Ortho. 2020 Oct 8;22:485-492
Lim JA, Loh B, Sylvestor G, Khan W. Perioperative management of distal radius fractures. J Perioper Pract. 2020 Sep 8;1750458920949463. [Online ahead of print]
Mostafa AMHAM, Kyriacou H, Chimutengwende-Gordon M, Khan WS. An overview of the key principles and guidelines in the management of pelvic fractures. J Perioper Pract. 2020 Sep 8;1750458920947358.
Hulme CH, Perry J, Roberts S, Gallacher P, Jermin P, Wright KT. Synovial fluid biomarker for the prediction of patient outcome following microfracture or osteomy. Orthopaedic Proceedings 103B (SUPP_2). 2020 Sept 8
Bongaerts M, Aizel K, Secret E, Jan A, Nahar T, Raudzus F, Neumann S, Telling N, Heumann R, Siaugue JM, Ménager C, Fresnais J, Villard C,El Haj A, Piehler J, Gates MA, Coppey M. Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces. Int J Mol Sci. 2020 Sep 8;21(18):6560.
Eldridge SE, Barawi A, Wang H, Roelofs A, Henson F, McCaskie AM, De Bari C, et al. Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis. Science Translational Medicine. 2020 Sep 2;12(559) eaax9086
Seefried L, Blyth M, Maheshwari R, McDonnell SM, et al. Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study. Ther Adv Musculoskelet Dis. 2020 Aug 29;12:1759720X20943088. eCollection 2020.
Dudman J, Ferreira AM, Gentile P, Wang XN, Ribeiro R, Benning M, Dalgarno K. Reliable inkjet printing of chondrocytes and MSCs using reservoir agitation. Biofabrication. 2020 Aug 12; 12(4)
Chakrabarti S, Ai M, Henson FMD, St. John Smith E. Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies. Neurobiology of Pain. 2020 July 28. [Epub]
Basyuni S, Ferro A, Santhanam V, Birch MA, McCaskie AW. Systematic scoping review of mandibular bone tissue engineering. Br J Oral Maxillofac Surg. 2020 58(6) 632-642
Migliorini F, Berton A, Salvatore G, Candela V, Khan WS, Longo UG, Denaro V. Autologous chondrocyte implantation and mesenchymal stem cells for the treatments of chondral defects of the knee- a systematic review. Curr Stem Cell Res Ther. 2020;15(6):547-556.
To K, Romain K, Mak C, Kamaraj A, Henson F, Khan W. The Treatment of Cartilage Damage Using Human Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Systematic Review of in vivo Studies. Front Bioeng Biotechnol 2020 Jun 11;8:580. [eCollection 2020]
Perry J, McCarthy HS, Bou-Gharios G, van ‘t Hof R, Milner PI, Mennan C, Roberts S. Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. Osteoarthritis and Cartilage Open.2020 Jun;2(2):100044.
Zhang H, Whalley RD, Ferreira AM, Dalgarno K. High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches. Progress in Biomedical Engineering. 2020 May 22;2(2)
Kaggie JD, Markides H, Graves MJ, MacKay J, Houston G, El Haj A, Gilbert F, Henson FMD. Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model. Sci Rep. 2020 May 21;10(1):8451.
Paterson YZ, Cribbs A, Espenel M, Smith EJ, Henson FMD, Guest DJ. Genome-wide transcriptome analysis reveals equine embryonic stem cell-derived tenocytes resemble fetal, not adult tenocytes. Stem Cell Research & Therapy 2020 May 19;11(184)
Samartzis D, Blumenthal S, Fairbank J, Fraser RD, Gunzburg R, Luk KDK, Roberts S, O’Brien JP: 2020 ISSLS Wiltse Lifetime Achievement Award. Spine (Phila Pa 1976). 2020 May 15;45(10):635-640.
Chisari E, Rehak L, Khan WS, Maffulli N. The Role of the Immune System in Tendon Healing: A Systematic Review. Br Med Bull. 2020 May 15;133(1):49-64.
Ranmuthu CDS, Ranmuthu CKI, Russell JC, Singhania D, Khan WS. Evaluating the Effect of Non-cellular Bioactive Glass-Containing Scaffolds on Osteogenesis and Angiogenesis in in vivo Animal Bone Defect Models. Front Bioeng Biotechnol. 2020 May 14;8:430.
JW MacKay, TD Turmezei, J Kaggie, AR Morgan, R Janiczek, WS Khan, S McDonnell, MJ Graves, GM Treece, AW McCaskie, FJ Gilbert. Three-dimensional Surface-based Analysis of Cartilage MRI data in Knee Osteoarthritis: Validation and Initial Clinical Application. JMRI 52(4):1139-1151. PMID: 32447815
Bojanic C, To K, Zhang B, Mak C, Khan WS. Human umbilical cord derived mesenchymal stem cells in peripheral nerve regeneration. World J Stem Cells. 2020 Apr 26;12(4):288-302.
Kyriacou H, Khan WS. Important perioperative factors, guidelines and outcomes in the management of hip fracture. J Perioper Pract. 2020 Apr 17:1750458920915656.
Eisenstein SM, Balain B, Roberts S. Current treatment options for intervertebral disc pathologies. Cartilage 11:143-151. 2020 Apr;11(2):143-151.
Brown SJ, Turner SA, Balain B, Davidson N, Roberts S. (2020) Is osteogenic differentiation of human nucleus pulposus cells a possibility for biological spinal fusion? Cartilage 2020 Apr;11(2):181-191
Hotham WE, Henson FMD. The use of large animals to facilitate the process of MSC going from laboratory to patient-‘bench to bedside’. Cell Biology and Toxicology. 2020 Mar 23 [Epub]
Agarwal N, To K, McDonnell S, Khan W. Clinical and Radiological Outcomes in Robotic-Assisted Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. J Arthroplasty. 2020 Mar 11:S0883-5403(20)30234-5.
Turmezei T, Treece G, Gee A, Sigurdsson S, Jonsson H, Aspelund T, Gudnason V, Poole KES. Quantitative 3D imaging parameters improve prediction of hip osteoarthritis outcome. Scientific Reports 2020 Mar 5;10(1):4127.
Sieberath A, Della Bella E, Ferreira AM, Gentile P, Eglin D, Dalgarno K. A comparison of osteoblast and osteoclast in vitro co-culture models and their translation for preclinical drug testing applications. International Journal of Molecular Sciences. 2020 Feb;21(3):912
Migliorini F, Berton A, Salvatore G, Candela V, Khan W, Longo UG, Denaro V. Autologous Chondrocyte Implantation and Mesenchymal Stem Cells for the Treatments of Chondral Defects Of The Knee- A Systematic Review. Curr Stem Cell Res Ther. 2020 Feb 21.
Roberts S, Kandel R Special Spine Issue Introduction. Cartilage. 2020 Feb 20; 11:141-142
Hernandez PA, Wells J, Usheva E, Nakonezny PA, Barati Z, Gonzalez R, Kassem L, Henson FMD. Early-Onset Osteoarthritis originates at the chondrocyte level in Hip Dysplasia. Sci Rep. 2020 Jan 17;10(1):627.
Kwan H, Chisari E, Khan WS. Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects. Materials (Basel). 2020 Jan 9;13(2):306.
Chisari E, Yaghmour KM, Peat F, Khan W. Patients Presenting with a Hot, Swollen Joint: A Single-Centre Retrospective Analysis. Curr Rheumatol Rev. 2020;16(1):38-42.
Books and Chapters:
Iyer K and Khan WS. (eds) (2020) Orthopedics of the Upper and Lower Limb. Springer, Cham.
Davies BM and Khan WS (2020) Stem Cell Therapy in Orthopedics. In: Iyer K., Khan W. (eds) Orthopedics of the Upper and Lower Limb. Springer, Cham. pp 565-572
De Bari C, Roelofs AJ. Stem and progenitor cells in synovium. Encyclopaedia of Bone Biology (In Press)
Luyten FP, De Bari C, Dell’Accio F. Regenerative Medicine and Tissue Engineering. Kelley’s Textbook of Rheumatology (11th Edition) (In Press)
