1. Clinical Analysis
To establish and utilise a reverse translational clinical sample analysis derived from ethically obtained specimens from human patients in clinical trials for analysis (biomarkers, phenotype and transcription)
2. Clinical Studies
To perform clinical trials in humans with culture-expanded and minimally manipulated cell therapy.
3. Clinically relevant cells
To define strategies to identify, select and assess potency in clinically relevant cell populations.
4. Cell sub populations
To consider the relevant biology of stem cells and their sub populations in musculoskeletal regeneration.
5. Tracking after cell delivery
To characterise the exogenous cell behaviour during repair and surgical intervention.
6. Tracking endogenous stem cells
To understand endogenous stem cell behaviour in the context of targeted molecular approaches to joint surface repair.
7. Pre-clinical studies
To specify and utilise appropriate pre-clinical development.